Mandy Juruni's side will face a KIU side with familiar faces from last year's finals.
City Oilers have been winning the last game for the last eight National Basketball League seasons.
However, their performance on the season's openers can be more consistent. But, of course, they wouldn't care about that, would they?
Winning the last game of the season, as they did against Namuwongo Blazers last October, means lifting the title, which is the ultimate target.
The eight-time league winners will face KIU Titans in the opening game of the 2023 season that tips off Friday night at the Lugogo Indoor Stadium.
In the fixture released on Monday by Fuba, Mandy Juruni's side will face a KIU side with familiar faces from last year's finals.
Saidi Amisi, Peter Obleng and Collins Kasujja were all with the Blazers when Oilers endured seven games to win the championship with just two points.
A 66-64 victory in Game Seven left Oilers lonely at the top, but it is a new season, and the Titans look like they mean business this time round.
Innocent Ochera and Brian Opiyo are the other new signings for Julius Lutwama's side.
The oilers, on the other hand, signed the best prospects in Ugandan basketball.
Fayed Baale and Titus Lual have already featured for the team in the Basketball Africa League qualifiers but will make their league debut for the club after crossing from UCU Canons.
The very first game of the new season will see a repeat of last year's finals match-up between UCU Lady Canons and JKL Lady Dolphins.
There have been changes on both sides, with Agatha Kamwada switching from the Lady Canons to the Lady Dolphins.
And in a bid to get back the championship they lost in last season's Game Seven, Henry Malinga's side added Leticia Awor and Becky Longom from KCCA Leopards.
The two games set for Friday will only serve as openers, with an action-packed weekend to follow on Saturday and Sunday.
National Basketball League
Opening fixtures (Friday, Lugogo)
UCU Lady Canons vs. JKL Lady Dolphins -7pm
KIU Titans vs. City Oilers -9pm