Gabriel Magalhaes scored the only goal of the game as Arsenal earned a crucial 1-0 win against Ange Postecoglou's Tottenham in the North London derby.
Arsenal came into this game without the injured duo - captain Martin Odegaard and new signing Riccardo Calafiori, as well as Declan Rice who was missing through suspension.
The onus was on the hosts to make the most of Arsenal's absentees and they started the game on the front foot, forcing Mikel Arteta's men to retreat, as the absence of Odegaard and Rice was telling in the middle of the park.
Dejan Kulusevski tested David Raya with a shot and cross inside eight minutes but the Spaniard was equal to both as Spurs continued to put pressure on the Gunners' defence.
Tensions ran high, exemplified by Jurrien Timber's robust challenge on Pedro Porro, which earned Vicario one of seven yellow cards dished out in the opening 45 minutes – a Premier League record.
As the intensity increased, Brennan Johnson's tame effort was comfortably saved by David Raya, before Porro bravely blocked Bukayo Saka's attempt, conceding a corner.
Saka sent in the resulting corner and Gabriel rose unchallenged to power home a header, sparking jubilant celebrations among the Arsenal faithful.
Spurs poured forward in search of an equalizer, but Mikel Arteta's well-drilled defense held firm. Dejan Kulusevski's late strike whizzed narrowly over, allowing Arsenal to claim a hard-fought victory.