They will be home to a wobbly Wakiso Giants, who have only picked one win, a draw and suffered three defeats.
Champions Vipers SC play host to neighbors Wakiso Giants FC in the Uganda Premier League at the St Mary's Stadium, Kitende on Tuesday, hoping to push further their unbeaten start to the campaign.
The Venoms have garnered three victories and two draws in the first five games, to leave them fourth on the log with 11 points.
They will be home to a wobbly Wakiso Giants, who have only picked one win, a draw and suffered three defeats.
However, Vipers head coach Leonard Martins Neiva doesn't expect it easy against the Purple Sharks.
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In just his first season at the helm with the Royals, Ssenyondo has won all the five games that he taken charge of, collecting a maximum 15 points.
"We will have to be at our best to win because of the strength of the opposition," Neiva told the vlub media.
"I don't see any weaknesses in the Wakiso Giants side, but I knows if we are at our best we can create some."
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It's now five games into the new Uganda Premier League season, and he has started in each one of them, keeping three clean sheets and conceding just twice.
"I am confident in our team and I know we can beat anybody at St Mary's Stadium," the Brazilian summed.
Last time out, the two sides managed stalemates in both legs last season.
After a one-all stalemate at the Kabaka Kyabaggu Stadium, it ended in a goalless draw at Kitende in February this year.
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While Wakiso has never beaten Vipers in League history, encounters between the two are oftentimes cagey.
Even then, Vipers has still managed three victories while the other five have ended without a winner.